Research Projects Directory

Research Projects Directory

14,430 active projects

This information was updated 11/21/2024

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. Each project specifies whether Registered Tier or Controlled Tier data are used.

Note: Researcher Workbench users provide information about their research projects independently. Views expressed in the Research Projects Directory belong to the relevant users and do not necessarily represent those of the All of Us Research Program. Information in the Research Projects Directory is also cross-posted on AllofUs.nih.gov in compliance with the 21st Century Cures Act.

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3 projects have 'acute myeloid leukemia' in the scientific questions being studied description
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Lipids and Cancer

Our laboratory has recently outlined cancer health disparities for Hispanic patients diagnosed with acute myeloid leukemia who live near the United States/Mexico border. In a separate project, we have associated lipid metabolism with outcomes in myeloid malignancies. In the present…

Scientific Questions Being Studied

Our laboratory has recently outlined cancer health disparities for Hispanic patients diagnosed with acute myeloid leukemia who live near the United States/Mexico border. In a separate project, we have associated lipid metabolism with outcomes in myeloid malignancies. In the present study, we hypothesize that blood lipid levels available in electronic health records will correlate with outcomes in Hispanic patients with acute myeloid leukemia.

Project Purpose(s)

  • Disease Focused Research (myeloid leukemia)
  • Population Health
  • Ancestry

Scientific Approaches

We will use electronic health records available for Hispanic versus non-Hispanic patients diagnosed with acute myeloid leukemia.

Anticipated Findings

The ultimate goal is to identify prognostic metrics for predicting therapy response and outcomes.

Demographic Categories of Interest

  • Race / Ethnicity
  • Geography

Data Set Used

Controlled Tier

Research Team

Owner:

  • Jose Andrade - Graduate Trainee, Texas Tech University Health Sciences Center at El Paso
  • Cristobal Lujan Martino - Graduate Trainee, Texas Tech University Health Sciences Center at El Paso
  • Anna Eiring - Early Career Tenure-track Researcher, Texas Tech University Health Sciences Center at El Paso
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Genomic analysis of blood samples

Determine genetic mutations within blood cells of individuals diagnosed with acute myeloid leukemia. Acute myeloid leukemia is a deadly disease with poor prognosis. This study will help identify novel therapeutic targets to improve treatment efficacy and ultimately overall survival in…

Scientific Questions Being Studied

Determine genetic mutations within blood cells of individuals diagnosed with acute myeloid leukemia.
Acute myeloid leukemia is a deadly disease with poor prognosis. This study will help identify novel therapeutic targets to improve treatment efficacy and ultimately overall survival in patients.

Project Purpose(s)

  • Disease Focused Research (acute myeloid leukemia)

Scientific Approaches

To determine mutational status of cells in blood samples, whole exome sequencing data will be first aligned to reference human genome, and mutations will be detected using Mutect2 algorithm.

Anticipated Findings

We anticipate to identify novel mutated genes within blood samples of acute myeloid leukemia patients, which can ultimately help in designing novel therapeutic strategies to improve survival in patients.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Controlled Tier

Research Team

Owner:

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leukemia

Leukemia is a cancer of the white blood cells, which begins in the bone marrow. There are four major types of leukemia, acute leukemia, chromonic lymphocytic leukemia, acute myeloid leukemia, and chorionic myeloid leukemia. The American Cancer Society's estimates for…

Scientific Questions Being Studied

Leukemia is a cancer of the white blood cells, which begins in the bone marrow. There are four major types of leukemia, acute leukemia, chromonic lymphocytic leukemia, acute myeloid leukemia, and chorionic myeloid leukemia. The American Cancer Society's estimates for leukemia in the Unites States for 2023 are about 59619 new cases of leukemia of all kinds and 23710 death form leukemia. Among the new cases, about 20380 new cases of acute myeloid leukemia, and most of them are adult cases. Our group want to find out by exploring the data what are the factors that put some people at higher risk on Leukemia, and also we want to find out the mortality rates for the leukemia patients with different demographics. In addition, we want to find out how many days hospitalization dates when patients are diagnosed with leukemia.

Project Purpose(s)

  • Disease Focused Research (leukemia)
  • Population Health
  • Social / Behavioral
  • Methods Development

Scientific Approaches

We want to find out by exploring the data what are the factors that put some people at higher risk on Leukemia, and also we want to find out the mortality rates for the leukemia patients with different demographics. In addition, we want to find out how many days hospitalization dates when patients are diagnosed with leukemia.

Anticipated Findings

Delays in diagnosis can have a significant impact on the outcomes of patients, relating to survival, response to treatment and even quality of life for the patient. We like to diagnose the leukemia as early as possible to treat the patients.

Demographic Categories of Interest

This study will not center on underrepresented populations.

Data Set Used

Registered Tier

Research Team

Owner:

  • In Hye Park - Graduate Trainee, George Mason University

Collaborators:

  • Nikhitha Telagamalla - Graduate Trainee, George Mason University
  • Jieun Jang - Graduate Trainee, George Mason University
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