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Data Access Tiers

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Achieving a Representative Sample of Asian Americans in Biomedical Research Through Community-Based Approaches: Comparing Demographic Data in the All of Us Research Program With the American Community Survey

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A new study to better understand the health outcomes of sexual and gender minority people

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Mitchell R. Lunn, MD, MAS, FACP, FASN Assistant Professor of Medicine and of Epidemiology and Population Health at Stanford University School of Medicine HEALTH OUTCOMES…

Data Methods

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Testing assumptions about cardiovascular health in underrepresented groups

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Julián Acosta, MDPostdoctoral Research Fellow, NeurologyYale School of Medicine Guido Falcone, MD, ScD, MPHAssistant Professor of Neurology; Director of Clinical Research in Neurocritical CareYale School…

Prevalence and comorbidity burden of prurigo nodularis in United States adults enrolled in the All of Us research program

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Balancing efficacy and computational burden: weighted mean, multiple imputation, and inverse probability weighting methods for item non-response in reliable scales

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Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

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A comprehensive analysis of lung cancer highlighting epidemiological factors and psychiatric comorbidities from the All of Us Research Program

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What is the composition of the All of Us cohort?

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All of Us aims to engage a cohort of 1 million or more participants that reflects the rich diversity of America, including populations that have…

Replicating published findings on hypertension prevalence in diverse populations

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Paulette D. Chandler, MD, MPHAssistant Professor, Medicine - Harvard Medical SchoolAssociate Physician, Medicine - Brigham And Women's Hospital Validating the hypertension algorithm Hypertension (HTN) is…

Privacy Policy

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All of Us Research Hub Privacy Policy The following privacy policy discloses the information gathering and dissemination practices for the Vanderbilt University Medical Center (“VUMC”)…

Studying the link between discrimination and depressive symptoms

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Younga “Heather” Lee, PhDPostdoctoral Research Fellow, Massachusetts General Hospital, Harvard Medical School, Broad Institute of MIT and HarvardSmoller Laboratory, Psychiatric & Neurodevelopmental Genetics Unit, Center…

An exploration of reproductive health issues that disproportionately affect Black women

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Nyia L Noel, MD, MPH Assistant Professor of Medicine Boston University School of Medicine Studying racial disparities in the prevalence of hypertensive pregnancy disorders and…

Comparing medical history data derived from electronic health records and survey answers in the All of Us Research Program

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Psychiatric comorbidities associated with granuloma annulare: A case-control study in the All of Us database

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A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

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Benchmarking computational variant effect predictors by their ability to infer human traits

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Empowering the biomedical research community: Innovative SAS deployment on the All of Us Researcher Workbench

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Comparison of phenomic profiles in the All of Us Research Program against the US general population and the UK Biobank

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Drug-Induced Liver Injury with Commonly Used Antibiotics in the All of Us Research Program

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Data Snapshots

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Data Snapshots These aggregated, public-facing data snapshots provide an overview of All of Us Research Program participant characteristics and the types of data that we…

Engaging Sexual and Gender Minority (SGM) Communities for Health Research: Building and Sustaining PRIDEnet

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What data are available for download in the Researcher Workbench?

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The Researcher Workbench protects participant data by enabling researchers to analyze All of Us data within the Researcher Workbench without taking the participant-level data out…

Examining the burden of psoriasis and psoriatic arthritis in a US adult cohort using the All of Us Research Program

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Burden of atopic disease in Black and Hispanic patients with alopecia areata: a case-control study in the All of Us research program

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Drug Exposures

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ADVILMED, ALLBUPEN, ALLIPEN, ALLIPEN FOR CHILDN, ALLIPEN FOR CHILDREN, ALOPAN, ALUPEN, ANTARENE, ANYFEN, ARTICOOLFEN, AUSTIN IBUPROFEN, Act-3, Actiprofen, Addaprin, Adedolor, Advel, Advil, Advil Plus, Aifeile,…

Antibiotic prescribing by age, sex, race, and ethnicity for patients admitted to the hospital with community acquired bacterial pneumonia (CABP) in the All of Us database

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Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program

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Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

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Computational phenotyping with the All of Us Research Program: identifying underrepresented people with HIV or at risk of HIV

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How rural is All of Us? Comparing characteristics of rural participants in the National Institute of Health’s All of Us Research Program to other national data sources

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Antibiotic prescribing by age, sex, race, and ethnicity for patients admitted to the hospital with community-acquired bacterial pneumonia (CABP) in the All of Us database

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Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program

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Associations between healthcare utilization and access and diabetic retinopathy complications using All of Us nationwide survey data

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The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD

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Association of autoimmune comorbidities with lichen planus: A US-based case-control study in the All of Us research program

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Barriers to care and health-related quality of life among US adults with several common chronic inflammatory skin diseases: a cross-sectional analysis of the NIH All of Us Research Program

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Comorbidities associated with mycosis fungoides: A case-control study in the All of Us database

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Increased risk of keloids in atopic dermatitis patients with allergic comorbidities: an all of us database analysis

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A retrospective case-control analysis of various comorbidities associated with Merkel Cell Carcinoma

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Association of Daily Step Count and Postoperative Complication among All of Us Research Participants

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Comparison of family health history in surveys vs electronic health record data mapped to the observational medical outcomes partnership data model in the All of Us Research Program

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Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study

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Psychiatric comorbidities associated with rosacea: A propensity score-matched case-control study in the All of Us database

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Comorbidities of psoriasis in underrepresented patient populations: An All of Us database analysis

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Comparing COVID-19 vaccination coverage, adverse reactions and impact of social determinants of health on vaccine hesitancy in ADRD/MCI and non-ADRD/MCI population: protocol for a retrospective cross-sectional study

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Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program

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Comorbidities associated with granuloma annulare: A case-control study in the All of Us research program

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Research participation in marginalized communities — overcoming barriers

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Cardiovascular comorbidities are associated with dermatomyositis: A cross-sectional study in the All of Us Research Program

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Sarcoidosis Is Associated With Hematologic Comorbidities: A Cross-Sectional Study in the All of Us Research Program

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Autoimmune and Cutaneous Inflammatory Comorbidities in Adult-Onset Morphea in the All of Us Research Program

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Engagement with health research summaries via digital communication to All of Us participants

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Returning value to the community through the All of Us Research Program Data Sandbox model

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Lice in adult patients is associated with psychiatric comorbidities and unstable housing in a matched case-control study using the All of Us Database

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Communicating research findings as a return of value to All of Us Research Program participants: insights from staff at Federally Qualified Health Centers

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Psychiatric comorbidities of Hidradenitis suppurativa in underrepresented groups: a case-control study utilizing the All of Us research program

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Epidemiology of alopecia areata in the Hispanic/Latinx community: A cross-sectional analysis of the All of Us database

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Comorbidities associated with discoid lupus erythematosus: A case-control study in the All of Us Research Program

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Neuropsychiatric complications and associated management in adolescent and young adult cancer survivors: An All of Us study

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Obsessive-compulsive disorder among patients with atopic dermatitis: a case-control study in the All of Us research program

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Keloids and associated comorbidities in underrepresented populations: a cross-sectional analysis of the All of Us database

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Prevalence, Comorbidity, and Sociodemographic Correlates of Psychiatric Disorders Reported in the All of Us Research Program

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Comorbid psychiatric disease significantly mediates increased rates of alcohol use disorder among patients with inflammatory and pigmentary skin disorders: a case-control study in the All of Us Research Program

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Learning important common data elements from shared study data: The All of Us program analysis

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Computational Phenotyping of OMOP CDM Normalized EHR for Prenatal and Postpartum Episodes: An Informatics Framework and Clinical Implementation on All of Us

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Prevalence of 12 Common Health Conditions in Sexual and Gender Minority Participants in the All of Us Research Program

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Vitiligo in underrepresented communities: An All of Us database analysis

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Nationwide Case-Control Analysis of Merkel Cell Carcinoma and Associated Skin Cancer Comorbidities: An Examination of the All of Us Database

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Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the  All of Us  research program

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De-black-boxing health AI: demonstrating reproducible machine learning computable phenotypes using the N3C-RECOVER Long COVID model in the All of Us data repository

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How does All of Us assess diversity? What communities does All of Us consider “underrepresented in biomedical research?”

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All of Us is committed to engaging a cohort that is demographically, geographically, and medically diverse. Specifically, these are the populations the program considers underrepresented…

Where does the data come from?

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The data in the All of Us Data Browser comes from participant electronic health records and from survey answers and physical measurements taken at the…

Creating a more personalized, risk-based approach to breast cancer screening 

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Elizabeth S. Burnside, MD, MPH, MS, FACRProfessor, RadiologyAssociate Dean, Team Science and Interdisciplinary Research, University of Wisconsin School of Medicine and Public HealthDeputy Executive Director,…

New study fuels debate about the Latino Epidemiological Paradox in the U.S.

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Olveen Carrasquillo, MD, MPHChief, Division of General Medicine - University of Miami;Miller School of Medicine Principal Investigator - All of Us Research Program at University…

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Researcher Workshops and Public Input

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Researcher Workshops and Public Input The All of Us Research Program is collecting data with unprecedented depth and diversity. We are using many tools to…

Data Access Framework

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Below are some key points from the Data Access Framework. The full document is available for download at the bottom of this page. The Data…

Ethical Conduct of Research Policy

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The All of Us Research Program requires authorized users of the All of Us data to conduct research that follows and conforms to the ethical…

Survey Explorer

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Survey Explorer Participants in the All of Us Research Program respond to surveys spanning a variety of topics. The program has tested each survey for…

Determining the prevalence of autoimmune diseases in the U.S.

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Aaron Abend, M.B.A.Executive Director, Autoimmune Registry; Managing Director, Prognosis Data Corp; Member, All of Us Advisory Panel Emily HolladayMasters in Public Health (MPH) student, The…

Data User Appeals Policy

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Below are some key points from the All of Us Research Program Data User Appeals policy. Data users should follow the full policy, available for…

Development of Participant Provided Information Modules for the All of Us Research Program

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Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension

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COPE survey sheds light on the pandemic’s effects on physical and mental health

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Holly Garriock, PhDChief CohortDevelopment OfficerAll of Us Research Program, National Institutes of Health Jordan Smoller, MD, SCDAssociate Chief for Research, Department of Psychiatry, Massachusetts General…

Researcher Workbench

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Robust estimation of heterogeneous treatment effects: an algorithm-based approach

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COVID-19 Research Initiatives

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Data User Code of Conduct (DUCC)

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Below are some key points from the All of Us Research Program Data User Code of Conduct. The full agreement is available for download at…

Policy on Stigmatizing Research

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Below are some key points from the policy on Stigmatizing Research. Data users should follow the full policy, available for download at the bottom of…

Publication and Presentation Policy

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Below are some key points from the Publication and Presentation policy. Data users should follow the full policy, available for download at the bottom of…

Data and Statistics Dissemination Policy

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Below are some key points from the All of Us Research Program Data and Statistics Dissemination Policy. Data users should follow the full policy, available…

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis

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Data Sources

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Data Roadmap In the coming years, All of Us will enroll more participants and make more types of data available, as funding allows. Data availability…

Best Practices for Participant and Stakeholder Engagement in the All of Us Research Program

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Diversity and inclusion for the All of Us research program: A scoping review

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The Impact of COVID-19 on the All of Us Research Program

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The All of Us Research Program: Data quality, utility, and diversity

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Phenome-wide association studies

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The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research

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Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats

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Establishing a National Engagement Strategy for Recruiting Asian Americans and Other Minorities into Biomedical Research

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Utilizing a Social-Ecological Health Promotion Framework to Engage Diverse Populations for Recruitment in the All of Us Research Program

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What if I have trouble signing in to the Researcher Workbench?

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The All of Us Researcher Workbench uses Google sign in for all accounts.  This requires users to authenticate their account with Google and set cookies…

About the Research Hub

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About the Research Hub The All of Us Research Hub matches a broad research community with a diverse set of research participants. Its goal is…

Researchers as Partners

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Researchers as Partners We believe a diverse and broadly accessible data resource can help us build a healthier future. The All of Us Research Program…

How are you gathering and curating information from electronic health records?

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The All of Us Research Program employs Observational Medical Outcomes Partnership (OMOP) Common Data Model Version 5 infrastructure to ensure feasibility and standardization across electronic…

How are participants recruited, and what does participation entail?

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Many participants are invited to enroll by one of our partner health care provider organizations, which include large academic medical centers, VA medical centers, and…

What is RxNorm?

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RxNorm is a naming system for all medications available in the U.S. market. The name of each drug is a compilation of its active ingredients,…

Do I need Institutional Review Board (IRB) approval from my own institution in order to access this data through the Researcher Workbench?

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Researchers should always check with their local institutional review board to ensure compliance with local requirements for conduct of research. We have provided the template…

What is genetic ancestry?

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The Data Browser includes calculated genetic ancestry associations of variants. Genetic ancestry shows the part of the world where an individual’s ancestors may have lived.…

What is OMOP?

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The All of Us Research Program employs Observational Medical Outcomes Partnership (OMOP) Common Data Model Version 5 infrastructure to ensure feasibility and standardization across all…

Is there a cost to use the Researcher Workbench?

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There is no cost to access the Researcher Workbench. Computation costs for analyses, however, may be incurred through Google Cloud Platform. The All of Us…

Data & Tools

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Machine learning algorithms to predict major adverse cardiovascular events in patients with diabetes

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Psoriasis is associated with increased risk of other autoimmune diseases: A retrospective case-control study using the All of Us research database

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Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease

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What resources are available for researchers interested in survey data?

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Participants in the All of Us Research Program respond to surveys spanning a variety of topics, including demographics, health care, and lifestyle. Each survey has…

Have participants consented to share this data?

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Yes, all participants consent to participate in the All of Us Research Program. To learn more, visit: https://www.joinallofus.org/what-participants-share

Can I use my personal or institutional SAS account to analyze the All of Us dataset?

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You cannot use your personal or institutional SAS login or SAS software to analyze the All of Us dataset. You must use SAS Studio within…

Physical Activity and Incident Obesity Across the Spectrum of Genetic Risk for Obesity

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Harnessing Consumer Wearable Digital Biomarkers for Individualized Recognition of Postpartum Depression Using the All of Us Research Program Data Set: Cross-Sectional Study

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Investigating the Protective Role of the Mitochondrial 2158 T > C Variant in Parkinson’s Disease

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Association of step counts over time with the risk of chronic disease in the All of Us Research Program

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I can drive in Iceland: Enabling international joint analyses

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Precision medicine in 2030—seven ways to transform healthcare

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Design and Implementation of the All of Us Research Program COVID-19 Participant Experience (COPE) Survey

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Association of longitudinal activity measures and diabetes risk: an analysis from the NIH All of Us Research Program

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Racial and Ethnic Disparities in Antihypertensive Medication Prescribing Patterns and Effectiveness

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The “All of Us” Research Program. Reply

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The “All of Us” Research Program

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Daily Step Counts Before and After the COVID-19 Pandemic Among All of Us Research Participants

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Is the data from the All of Us serology study, highlighted in Clinical Infectious Diseases, available to researchers?

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Within the Researcher Workbench, a series of five tables enables All of Us researchers to replicate the analysis described in the journal article.1 At this…

Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020

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Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension

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Systematic replication of smoking disease associations using survey responses and EHR data in the All of Us Research Program

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Data-driven science and diversity in the All of Us Research Program

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Rethinking Data Collection Methods During the Pandemic: Development and Implementation of CATI for the All of Us Research Program

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Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation

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Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort

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Do researchers have to pay a licensing fee for SAS in the Researcher Workbench?

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SAS must be licensed for use, so many researchers are used to paying for this license. At this time, registered researchers do not need to…

Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups

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An ensemble penalized regression method for multi-ancestry polygenic risk prediction

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Privacy & Security Protocols

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Privacy & Security Protocols The All of Us Research Program uses high-quality security technology to help keep participant data safe. The data that participants give…

A machine learning model identifies patients in need of autoimmune disease testing using electronic health records

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Research Roundup 10/23

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Taking health information to the next level: Strategic partnerships between NLM and public libraries

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Research Roundup 6/23

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Register

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What tools will be available for me to analyze the data?

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The Researcher Workbench features several tools to support data analysis: Workspace: A workspace is the place to store and analyze data for a specific project.…

Will the All of Us cohort offer a representative sample of U.S. citizens?

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No. The All of Us participant community will reflect the diversity of the United States, but cannot be described as a representative sample. Participants are…

How is the All of Us Research Program different from other longitudinal cohort studies?

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Unlike many research studies that focus on a specific disease or population, the All of Us Research Program will provide a national research resource to…

Deep learning of left atrial structure and function provides link to atrial fibrillation risk

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Secure Discovery of Genetic Relatives across Large-Scale and Distributed Genomic Datasets

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What is the purpose of the Data Browser?

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The Data Browser is an interactive tool that allows you to learn more about the data collected as part of the All of Us Research…

What are analysis files?

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Analysis files are where researchers can perform comprehensive analyses on cohorts and data sets using programming languages R, Python, or SAS.

Am I obligated to share any publications with the program?

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Yes. As a condition of your data access, you must inform the program of any upcoming publications resulting from access to All of Us Research…

What is the Resource Access Board (RAB)?

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The Resource Access Board (RAB) is charged with reviewing and auditing research projects to determine whether they may potentially stigmatize research participants or violate the…

Why is my research project information shared publicly?

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The All of Us Research Program is committed to being transparent with its research participants about the purpose of the research that uses their data.…

What information about me is displayed publicly and why?

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The Research Projects Directory will display your name, institution, and role. This information will be displayed along with the Research Purpose Description you provided for…

How do I access the research data?

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Accessing the Researcher Workbench data is easy and takes only a few steps. If you are interested in applying for Researcher Workbench access, please visit…

What COVID-19 data are available in the Researcher Workbench now?

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The All of Us Data Dictionary provides researchers with the most robust description of data elements available within the Researcher Workbench. Between May 2020 and…

Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

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Is there a cost to use the All of Us genomic data?

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There is no cost for researchers to register with the All of Us Research Program and to begin working within the dataset. Researchers will incur…

Research Projects Directory

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The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is…

Polygenic risk alters the penetrance of monogenic kidney disease

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The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities

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Low-Income, Poor Physical Health, Poor Mental Health, and Other Social Risk Factors Are Associated With Decreased Access to Care in Patients With Carpal Tunnel Syndrome

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